|
|
PRIMARY ENDPOINT The primary endpoint in EPoS I, II and III is CRC incidence. CRC incidence will be compared in the different arms in EPoS I and II, and in EPoS III. SECONDARY ENDPOINTS The following endpoints will also be compared in the different arms in EPoS I and II, and in EPoS III
|
PREDEFINED SUBGROUP ANALYSES Subgroups defined by variables which may be associated with the risk of CRC and adenoma yield during follow-up will be analysed. These include: patient age and gender, reason for first colonoscopy (colonoscopy screening; colonoscopy after a positive screening test (FIT, FOBT, sigmoidoscopy;); clinical symptoms; other indications) and the following polyp characteristics: type of polyp, size of polyp, in case of adenoma: growth pattern (tubular, tubulovillous or villous), grade of dysplasia (high vs. low); multiplicity and location of polyps (proximal vs distal colon). |