JOINT INCLUSION CRITERIA FOR ALL EPOS TRIALS AT BASELINE COLONOSCOPY
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  • Men and women age 40-74 years
  • Cecal intubation (preferably documented by images/video of the appendiceal orifice and the ileocecal valve; but not required).
  • Adequate colonic cleansing, with Boston Bowel Cleansing Score equal or higher than 2 points in all colonic segments.
  • Complete excision of all polyps at baseline colonoscopy findings (as judged by the trial endoscopists)
  • Randomisation must be performed no longer than 26 weeks (182 days) from completion date of baseline colonoscopy


JOINT EXCLUSION CRITERIA FOR ALL EPOS TRIALS
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  • Lack of consent
  • History of CRC or adenomas
  • History of serrated polyps ≥ 10 mm in diameter at any colorectal location or ≥ 5 mm if located proximal to the splenic flexure
  • More than 10 adenomas
  • Incomplete colonoscopy / Incomplete endoscopic excision of polyps
  • Genetic cancer syndrome (adenomatous or serrated polyposis syndrome; Lynch or Lynch-like syndrome)
  • Inflammatory bowel disease
  • History of surgical colon resection for any reason
  • Severe co-morbidity with reduced life expectancy (NYHA 3-4)
  • On-going cytotoxic treatment or radiotherapy for malignant disease
  • Long-lasting attention and nursing services (somatic or psychosocial, mental retardation). ​