JOINT INCLUSION CRITERIA FOR ALL EPOS TRIALS AT BASELINE COLONOSCOPY

• Men and women age 40-74 years
  
• Cecal intubation (preferably documented by images/video of the appendiceal orifice and the ileocecal valve; but not required).
• Adequate colonic cleansing, with Boston Bowel Cleansing Score equal or higher than 2 points in all colonic segments.
  
• Complete excision of all polyps at baseline colonoscopy findings (as judged by the trial endoscopists)
• Randomisation must be performed no longer than 26 weeks (182 days) from completion date of baseline colonoscopy

JOINT EXCLUSION CRITERIA FOR ALL EPOS TRIALS

• Lack of consent
  
• History of CRC or adenomas
  
• History of serrated polyps ≥ 10 mm in diameter at any colorectal location or ≥ 5 mm if located proximal to the splenic flexure
• More than 10 adenomas
  
• Incomplete colonoscopy / Incomplete endoscopic excision of polyps
• Genetic cancer syndrome (adenomatous or serrated polyposis syndrome; Lynch or Lynch-like syndrome)
  
• Inflammatory bowel disease
  
• History of surgical colon resection for any reason
• Severe co-morbidity with reduced life expectancy (NYHA 3-4)
  
• On-going cytotoxic treatment or radiotherapy for malignant disease
  
• Long-lasting attention and nursing services (somatic or psychosocial, mental retardation). ​

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