Methods
JOINT DESIGN SETTING
EPoS I and II are randomised controlled trials. EPoS III is a one-arm observational study. Eligible for all trials are individuals with no history of CRC or adenomas between 40 and 74 years who have undergone colonoscopy with removal of one or more adenomas or serrated polyps at one of the study centres.
Patients can be included at any point in time between the baseline colonoscopy and the date of first surveillance colonoscopy.
Patients can be included at any point in time between the baseline colonoscopy and the date of first surveillance colonoscopy.
Surveillance colonoscopiesSurveillance colonoscopy is the intervention tool used in all trials. At surveillance colonoscopy, all detected polyps will be registered and described, removed whenever possible and subjected to histopathology. All required data from endoscopy reports, quality-data used for quality monitoring and histopathologic results must be registered in the central study database. Local pathology labs will serve the participating centres and perform histopathological analysis of the tissue samples. |
Time of surveillance colonoscopiesSurveillance colonoscopies are scheduled at the participating centres according to the time slots defined in the protocol for the different study groups and arms Surveillance colonoscopies are to be performed within a 6-month time interval from the protocol-defined date. Surveillance colonoscopies which are performed earlier than 6 months before or later than 6 months after the protocol-defined date are recorded as a protocol deviation. |